Views: 3 Author: Site Editor Publish Time: 2026-01-16 Origin: Site
The Remarkable Sulforaphane | Protecting Digestive System Health from the Gastrointestinal Tract to the Liver and Pancreas
As a country with a high incidence of digestive system diseases, China faces widespread health challenges such as chronic gastritis, gastroesophageal reflux disease, peptic ulcers, ulcerative colitis, and alcoholic/non-alcoholic liver diseases.
In recent years, sulforaphane (SFN), due to its outstanding biological activity, has achieved significant breakthroughs in the treatment and adjuvant therapy of digestive system diseases, providing a new direction for prevention and management.
Extensive studies have confirmed that sulforaphane exerts antioxidant and anti-inflammatory activities, playing a key protective role in multiple digestive organs including the gastrointestinal tract, liver, pancreas, and spleen, offering scientific support for the intervention of various digestive disorders.
Protective Effects of Sulforaphane (SFN) on the Gastrointestinal Tract
Helicobacter pylori (Hp) infection is very common in daily life and often causes chronic gastritis, which may further lead to gastric ulcers, duodenal ulcers, mucosa-associated lymphoid tissue lymphoma, and gastric cancer.
In a clinical trial involving 110 Hp-infected subjects, it was found that after consuming broccoli seed aqueous extract containing sulforaphane (SFN) daily for two consecutive months, the levels of inflammatory cytokines (mainly IL-8 and IFN-γ) were significantly reduced, effectively lowering the risk of gastric mucosal lesions and thereby preventing Hp-induced gastric cancer (ChiCTR2100054249).
Protective Effects of Sulforaphane (SFN) on the Liver
Non-alcoholic fatty liver disease (NAFLD) is a metabolic disorder associated with obesity and type 2 diabetes. In recent years, studies on sulforaphane (SFN) treatment of NAFLD and related targets have increased rapidly. Research shows that sulforaphane intervention significantly improves excessive lipid accumulation in hepatocytes of high-fat diet-induced fatty liver mice, while regulating hepatic and serum inflammatory responses and antioxidant levels.
Alcohol-induced cellular injury mainly involves lipid peroxidation and oxidative stress. Studies suggest a close association between alcoholic liver disease and oxidative stress. Experimental results demonstrate that sulforaphane combined with aerobic exercise can exert significant hepatoprotective effects by inhibiting lipid peroxidation, providing a new approach for repairing alcoholic liver injury.
Protective Effects of Sulforaphane (SFN) on the Pancreas and Spleen
In a caerulein-induced acute pancreatitis mouse model, sulforaphane (SFN) pretreatment significantly alleviated pancreatic edema, reduced serum amylase and myeloperoxidase (MPO) activity, and improved tissue damage.
Sulforaphane (SFN) enhances cytokine secretion capacity of splenic macrophages under LPS stimulation, significantly increasing levels of IL-6, IL-10, MCP-1, and other key factors, helping restore partial immune function of the spleen and supporting immune balance of the digestive system.
In summary, sulforaphane (SFN) exhibits protective effects against digestive system diseases such as gastric ulcers, gastric tumors, gastrointestinal and liver injuries caused by various drugs, ischemia-reperfusion-induced digestive injuries, and alcoholic or non-alcoholic liver diseases.
Pioneer Herb – Broccoli Extract Product Series
Sulforaphane generally exists in cruciferous vegetables in the form of its precursor glucoraphanin (GLR). Glucoraphanin is a naturally occurring thioglucoside compound with long-lasting antioxidant effects and can be converted into sulforaphane by intestinal microbiota or myrosinase.
Pioneer Herb has been deeply engaged in the R&D and production of broccoli extract GLR® Broc Pio®, offering four major product categories with multiple specifications.
Product Category | Specification | Key Features |
Broccoli Seed Extract GLR® | Glucoraphanin 13%–20% | Pleasant taste, high solubility and clarity |
Activated Broccoli Seed Extract GLR® | Conversion rate 80% | High conversion efficiency, excellent stability |
Sulforaphane Broc Pio® | 1%, 10%, 95%, customized available | Fast absorption, high activity |
Micro-encapsulated Sulforaphane Broc Pio® | Sulforaphane 1%, 10% | Room temperature storage, excellent stability |
Product Features: Proprietary varieties, proprietary cultivation bases, 650 pesticide residues not detected, low heavy metals
Core Advantages:
• Exceptional stability with long-lasting activity ensured through advanced manufacturing and quality control technologies.
• High conversion rate and high bioavailability through optimized processes.
• Enhanced safety with 650 pesticide residue screenings and strict heavy metal testing.
• Excellent solubility and clarity, suitable for beverages and liquid products, with no bitterness.
• Fully traceable and stable quality supported by proprietary varieties, standardized cultivation bases, and full supply-chain quality control.
Application Scenarios:
Functional foods: solid beverages, gummy supplements, tablets, chocolates;
Dietary supplements: tablets, hard capsules, soft capsules, liquid drinks;
Special dietary foods.
Choosing Pioneer Herb means selecting not only a high-activity, high-safety ingredient, but also a complete quality assurance system from source to finished product.
⭐ If you have any inquiries regarding raw materials, samples, or technical consultation, please feel free to contact us.
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References:
[1]康正涛,谢庆芝.萝卜硫素在消化系统疾病治疗中的研究进展[J].中国现代医药杂志,2025,27(11):42-48.
[2]Guo K,Wang L,Mahe JL,et al.Correction to:effect of aqueousextract of seed of broccoli on inflammatory cytokines and Helicobacterpylori infection:a randomized, double-blind, controlled trial inpatients without atrophic gastritis[J].Inflammopharmacology,2022, 30(6):2549.
[3]Ma ST, Pang XY, Tian SH, et al. The protective effects ofsulforaphane on high-fat diet-induced metabolic associated fatty liverdisease in mice via mediating the FXR/LXRα pathway[J]. FoodFunct,2022,13(24):12966-12982.
[4]Wang J, Zhou HX. Protective effects of sulforaphane and aerobicexercise on acute alcoholic hepatic injury in mice[J].Saudi J BiolSci,2020,27(11):3145-3149.
[5]Dong ZJ, Shang HX, Chen YQ, et al. Sulforaphane protectspancreatic acinar cell injury by modulating Nrf2-mediated oxidativestress and NLRP3 inflammatory pathway[J]. Oxid Med CellLongev,2016,2016:7864150.
[6]Qin K, Li Y, Liang WQ, et al. Sulforaphane administration afterhemorrhagic shock/resuscitation in mice reduces the secretion ofinflammatory cytokines and increases the immunocompetence ofsplenic macrophages[J].Shock,2023,59(3):486-492.
